Call for proposal: The Ehlers-Danlos Society call 2018
Role: Coordinator
Responsible per UniBS: Prof. Marina Colombi– Departement of Molecular and Translational Medicine
Contact: marina.colombi@unibs.it
Start date 09/05/2019 – End date 08/05/2020
Abstract
Hypermobile Ehlers-Danlos syndrome/hypermobility spectrum disorders (hEDS/HSD) is the most common form of EDS, which is dominated by an extremely variable phenotype and a high rate of chronic disability. The etiology of hEDS/HSD is unknown, and patients are still without a definitive molecular diagnosis. Our previous studies demonstrated that hEDS/HSD fibroblasts exhibit a widespread extracellular matrix (ECM) disarray and significant expression changes of several genes involved in connective tissue architecture, and related to inflammatory, pain, and immune responses. These cells also show a proinflammatory matrix-degrading phenotype with a range of phenotypic features that are typical of myofibroblasts. Taking advantage from our cell model, in this project we plan to profile the proteome of hEDS/HSD patients’ dermal fibroblasts to identify specific proteomic signatures and perturbed biological processes that contribute to the pathophysiology of hEDS/HSD.
- UNIVERSITA’ DEGLI STUDI DI BRESCIA (Coordinatore), Italy
- UNIVERSITA’ DEGLI STUDI DI MILANO, Italy
- IRCCS CASA SOLLIEVO DELLA SOFFERENZA DI SAN GIOVANNI ROTONDO, Italy
Total project cost: US$ 50,000.00
Overall funding assigned to UniBS: US$ 32,000.00